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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolyl carbamates

Author(s): Vijaya Durga Thripuram, Hari Babu Bollikolla*, Siva Nagi Reddy Mule, Sailaja Kumari Battula and Vasu Babu Ala

Volume 15 , Issue 7 , 2018

Page: [569 - 574] Pages: 6

DOI: 10.2174/1570178614666170811121704

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An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and t-BuLi medium at -78°C to room temperature. The reactions were monitored with TLC for about 3-4 h. The yields obtained were also considerably good.

Keywords: α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole, imidazolyl carbamate.

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