MicroRNA Dysregulation in Alzheimer's Disease

Title:MicroRNA Dysregulation in Alzheimer's Disease

Volume: 16 Issue: 9

Author(s): Manish Putteeraj, Yahaya Mohamad Fairuz and Seong Lin Teoh*

Affiliation:

• Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur,Malaysia

Keywords: Alzheimer disease, microRNA, β-amyloid, Tauopathy, biomarker, treatment.

Abstract: Background and Objective: Alzheimer's disease (AD) is arguably the largest healthcare issue of our time. AD is thought to be principally the result of an inter-play between the β-amyloid peptide and Tau, and it is driven by several genetic and environmental risk factors. Recent studies have shown that small non-protein-coding microRNA (miRNA) and the associated post-transcriptional gene regulation are important regulators of many neurodegenerative diseases, including AD. We reviewed recent studies identifying various miRNA dysregulated in AD. These miRNAs could play a significant role in the pathophysiology of AD, in both β-amyloid peptide and Tau toxicity.

Conclusion: The identification of dysregulated miRNAs pattern can serve as specific AD biomarkers which may provide the basis for new and effective diagnostic approach. In addition, these miRNAs may represent new targets for pharmaceutical development.

Cite this article as:

Putteeraj Manish , Fairuz Mohamad Yahaya and Teoh Lin Seong *, MicroRNA Dysregulation in Alzheimer's Disease, CNS & Neurological Disorders - Drug Targets 2017; 16(9) . https://dx.doi.org/10.2174/1871527316666170807142311