Abstract
The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks.
This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.
Keywords: Anti-cancer, anti-HIV, anti-microbial, anti-oxidant, biological activities, indole.
Mini-Reviews in Medicinal Chemistry
Title:Recent Progress in Biological Activities of Indole and Indole Alkaloids
Volume: 18 Issue: 1
Author(s): Thokchom Prasanta Singh and Okram Mukherjee Singh*
Affiliation:
- Chemistry Department, Manipur University, Canchipur-795 003, Manipur,India
Keywords: Anti-cancer, anti-HIV, anti-microbial, anti-oxidant, biological activities, indole.
Abstract: The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks.
This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.
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Cite this article as:
Singh Prasanta Thokchom and Singh Mukherjee Okram *, Recent Progress in Biological Activities of Indole and Indole Alkaloids, Mini-Reviews in Medicinal Chemistry 2018; 18 (1) . https://dx.doi.org/10.2174/1389557517666170807123201
DOI https://dx.doi.org/10.2174/1389557517666170807123201 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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