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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article

Leber's Hereditary Optic Neuropathy: Novel Views and Persisting Challenges

Author(s): Jasna Jancic, Janko Samardzic*, Stevan Stojanovic, Amalija Stojanovic, Ana Marija Milanovic, Blazo Nikolic, Nikola Ivancevic and Vladimir Kostic

Volume 16, Issue 8, 2017

Page: [927 - 935] Pages: 9

DOI: 10.2174/1871527316666170724172455

Price: $65

Abstract

Background & Objective: Leber's hereditary optic neuropathy is an inherited form of optic neuropathy, genetically and pathophysiologically based on mitochondrial insufficiency causing bilateral loss of central vision mostly amongst young adults. Despite being one of the most common mitochondrial diseases, the explanation for its pathophysiological background and effective clinical solutions remain elusive. Widening the scope in the search for pathological findings beyond the optic system has yielded several non-ophthalmologic findings, which might imply that Leber's hereditary optic neuropathy is in fact a multi-systemic disease.

Conclusion: The aim of this review is to provide an overview of literature regarding the epidemiology, etiology, pathogenesis, clinical features, diagnostics and possible treatment options and drug targets, as well as presenting challenges related to the disease and proposing a diagnostic algorithm based on current clinical experience.

Keywords: Leber's hereditary optic neuropathy, epidemiology, etiopathogenesis, clinical features, drug targets, multi-systemic involvement, mitochondrial disease, ophthalmological manifestations.

Graphical Abstract

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