Gene Delivery with Organic Electronic Biomaterials

Kathryn    F.A.   Clancy; John    G.   Hardy

Abstract

Gene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors.

Keywords: Organic electronics, carbon nanotubes, fullerene, graphene, conjugated polymer, gene delivery, gene therapy, biodegradable.

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Current Pharmaceutical Design

Title:Gene Delivery with Organic Electronic Biomaterials

Volume: 23 Issue: 24

Author(s): Kathryn F.A. Clancy and John G. Hardy*

Affiliation:

Department of Chemistry and Materials Science Institute, Faraday Building, Faculty of Science and Technology, Lancaster University, Lancaster, Lancashire, LA1 4YB,United Kingdom

Keywords: Organic electronics, carbon nanotubes, fullerene, graphene, conjugated polymer, gene delivery, gene therapy, biodegradable.

Abstract: Gene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient’s cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors.

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Clancy F.A. Kathryn and Hardy G. John *, Gene Delivery with Organic Electronic Biomaterials, Current Pharmaceutical Design 2017; 23 (24) . https://dx.doi.org/10.2174/1381612823666170710124137

DOI https://dx.doi.org/10.2174/1381612823666170710124137	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286

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