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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO

Author(s): Hamzeh Kiyani*, Mohsen Tazari and Fatemeh Ghorbani

Volume 15 , Issue 6 , 2018

Page: [523 - 529] Pages: 7

DOI: 10.2174/1570178614666170710094547

Price: $65

Abstract

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation and hydrothermal treatment of aqueous salt solution as reported previously. The structure of nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively shorter reaction times are the advantages of this protocol.

Keywords: 2-Aminobenzamide, aldehyde, 2, 3-dihydroquinazolin-4(1H)-one, green, nano-MgO, water.

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