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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X


Editorial: Research and Selection of Multitarget Compounds in Medicinal Chemistry

Author(s): Luciana Scotti, Francisco Jaime Bezerra Mendonça and Marcus T. Scotti

Volume 24 , Issue 16 , 2017

Page: [1627 - 1628] Pages: 2

DOI: 10.2174/092986732416170704114736


In drug discovery, a hit series, with the desired primary and secondary activities, as well as physiochemical properties is identified such that the final agent will be useful when administered to real patients [1]. Medicinal chemistry can improve recognition and the binding geometries (pharmacophores) of candidate compounds, and their target’s affinity. Medicinal chemistry, in a modern view, is dedicated to understanding molecular mechanisms, chemical relationships, and the pharmacological activities involved in drug action thru pharmacodynamic and pharmacokinetic factors. The introduction of new technologies has become a prime concept in medicinal chemistry, expanding its interdisciplinary character. Most drugs are small bioactive molecules that interact with specific macromolecules or receptors, resulting in therapeutic effects. Modern computational methods determine...

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