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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Editorial

Editorial: DNA Damage as a Strategy for Anticancer Chemotherapy

Author(s): Maria Bozko, Andrzej Bozko, Tim Scholta, Nisar P. Malek and Przemyslaw Bozko*

Volume 24 , Issue 15 , 2017

Page: [1487 - 1487] Pages: 1

DOI: 10.2174/092986732415170630115722

Abstract

Amongst all currently used drugs in the field of cancer therapy, the most prominent group of agents which induce DNA, damage both directly or indirectly. Intuitively DNA should not be a perfect target for relatively unspecific small molecular weight drugs. However, the current understanding is that not damage per se but cellular response to DNA damage induced by antitumor agents is responsible for their specific targeted effect towards cancer cells in comparison to the normal cells. DNA damaging chemotherapeutics include compounds with diferent activities namely: directly or indirectly induce DNA strand breaks, covalently modify DNA bases, change the chromatin structure and topology by inhibiting chromatin-modifying enzymes. In this special issue of Current Medicinal Chemistry entitled....


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