Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Cyclin-Dependent Kinase Inhibitors: Cancer Killers to Neuronal Guardians

Author(s): E. A. Monaco III and M. L. Vallano

Volume 10 , Issue 5 , 2003

Page: [367 - 379] Pages: 13

DOI: 10.2174/0929867033368277

Price: $65


The development of small molecule kinase inhibitors as potential cancer therapeutics is an area of intense interest, and a subset of these agents target cyclindependent kinase (CDK) activity. Ten distinct CDKs (1-9, 11), when paired with their cyclin activators, are integral to such diverse processes as cell cycle control, neuronal development, and transcriptional regulation. Mutation and / or aberrant expression of certain CDKs and their regulatory counterparts are associated with uncontrolled proliferation and tumorigenesis. As such, CDK selective inhibitors (CDKIs) that attenuate or prevent tumor growth have been developed. Recently, interest in the therapeutic potential of CDKIs has expanded to include neurodegenerative diseases, where dysregulated CDK activity has been linked to the pathogenesis of Alzheimers disease (AD), amyotrophic lateral sclerosis (ALS), and stroke. Specifically, aberrant activation of cell cycle CDKs or CDK5 is associated with apoptosis and neuronal dysfunction in response to various neuronal stressors. To date, CDKIs have shown promise as neuroprotective agents in the research laboratory and, in the future, may prove useful in the neurology clinic.

Keywords: cyclin-dependent kinase inhibitors, cell cycle, cancer, neurodegeneration, alzheimers disease, amyotrophic lateral sclerosis, stroke

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy