Biosensors for Screening Kinase Inhibitors

Title:Biosensors for Screening Kinase Inhibitors

Volume: 17 Issue: 22

Author(s): Nikhil Bhalla*Pedro Estrela

Affiliation:

• Okinawa Institute of Science and Technology Graduate University (OIST) 1919-1 Tancha, Onna, Kunigami District, Okinawa Prefecture 904-0412,Japan

Keywords: Biosensors, Screening Kinase Inhibitors, protein phosphorylation, cancer, drug discovery.

Abstract: For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.

Cite this article as:

Bhalla Nikhil *, Estrela Pedro, Biosensors for Screening Kinase Inhibitors, Current Topics in Medicinal Chemistry 2017; 17(22) . https://dx.doi.org/10.2174/1568026617666170531113233