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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling

Author(s): Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha

Volume 26 , Issue 22 , 2019

Page: [4166 - 4177] Pages: 12

DOI: 10.2174/0929867324666170523140925

Price: $65


The pathophysiology linking diabetes and cardiovascular disease (CVD) is complex and multifactorial. The specific type of cardiomyopathy associated with diabetes, known as diabetic cardiomyopathy (DCM), is recognized as asymptomatic progression of structural and functional remodeling in the heart of diabetic patients in the absence of coronary atherosclerosis and hypertension. In other words, the presence of heart disease specifically in diabetic patients is also known as diabetic heart disease. This article reviews the impact of diabetes in heart and vascular beds focusing on molecular mechanisms involving the oxidative stress, the inflammation, the endothelium dysfunction and the alteration of the homeostasis of calcium, among others mechanisms. Understanding these mechanisms will help identify and treat CVD in patients with diabetes, as well as to plan efficient strategies to mitigate DCM impact in those patients.

Keywords: Cardiovascular disease, diabetes, diabetic cardiomyopathy, calcium homeostasis, oxidative stress, endothelial dysfunction.

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