Qualitative Estimation of Drug Entrapment Efficiency in Polymeric Nano - Micelles Using Dissipative Particle Dynamics (DPD)

Title:Qualitative Estimation of Drug Entrapment Efficiency in Polymeric Nano - Micelles Using Dissipative Particle Dynamics (DPD)

Volume: 5 Issue: 2

Author(s): Farzin Hadizadeh and Jamal Shamsara*

Affiliation:

• Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad,Iran

Keywords: Coarse-graining, DPD, drug entrapment efficiency, mesoscale, molecular dynamics, polymeric micelle.

Abstract: Background: Dissipative particle dynamics (DPD) is a simulation method that has one of its applications in the field of pharmaceutical science and drug delivery.

Objective: DPD is employed to study morphology and some other characteristics of polymeric nanomicelles. Two systems were considered in this study: system A which includes curcumin, Polycaprolactone (PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel, Polylactic acid (PLA), PEG and water beads.

Method: In this study we focused on the simulation of drug entrapment in polymeric micelles using DPD method.

Results: Results indicated that the qualitative comparison of polymeric-micelles with different compositions, after carefully tuning input parameters and simulation conditions, can be successfully performed using DPD.

Conclusion: Considering real state of a system for DPD simulation will have a great impact on the reliability of the simulation results.

Cite this article as:

Hadizadeh Farzin and Shamsara Jamal*, Qualitative Estimation of Drug Entrapment Efficiency in Polymeric Nano - Micelles Using Dissipative Particle Dynamics (DPD), Pharmaceutical Nanotechnology 2017; 5 (2) . https://dx.doi.org/10.2174/2211738505666170522152836

DOI https://dx.doi.org/10.2174/2211738505666170522152836	Print ISSN 2211-7385
Publisher Name Bentham Science Publisher	Online ISSN 2211-7393