Abstract
Aim and Objective: Chromenes are one of the most demanded compounds that are recognized for their unique pharmacological and biological activities. This report illustrates the synthesis of new chromene series and chromene based azo chromophores as first example and examines their biological applications in order to explore their possible biological and cytotoxic activities.
Material and Method: Using multicomponent methodology, two new families of 4H-chromene and chromene azo chromophores have been successfully synthesized. These compounds were evaluated for their antimicrobial activity as well as their cytotoxicity against three cancer cell lines. The docking simulations were performed for their structure-activity relationship analyses.
Results: Novel chromene and chromene azo chromophores have been synthesized successfully using multicomponent methodology. Several of these compounds showed significant potent antimicrobial activities compared to reference drugs. In addition, antiproliferative analysis against three target cell lines was examined. Compounds 4a, 4b, 4c, and 7c possessed significant antiproliferative activity with an IC50 of 0.3 to 2 µg/mL, while their docking study proved that the pharmacophore features played a crucial role in reducing the regulation of cancer cell signaling or apoptotic activation.
Conclusion: New derivatives of benzo chromene were obtained via multicomponent methodology. The new compounds were examined for their antimicrobial and antiproliferative activities. Molecular docking study was carried out to clarify the structural desires and target binding properties as a trial for explaining the structureactivity relationship profile
Keywords: 4H- chromenes, chromene based azo chromophores, antitumor activity, biological applications, docking simulations.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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