Asymmetric Catalysis in the Synthesis of Azaflavanones

Title:Asymmetric Catalysis in the Synthesis of Azaflavanones

Volume: 14 Issue: 5

Author(s): Sergio Pinheiro, Estela M.F. Muri*, Rafael P. R. F. de Oliveira, Luiza R.S. Dias and Sandro J. Greco

Affiliation:

• Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mario Viana 523, Santa Rosa, 24241-000, Niterói, RJ,Brazil

Keywords: Azaflavanones, Michael, aza-Michael, one-pot reactions, kinetic resolution, enantioselective epoxidation.

Abstract: Azaflavanones are synthetic aza-analogues of flavanones possessing several biological interests, especially as anticancer. Since individual enantiomers of azaflavanones showed different anticancer activities, the development of asymmetric routes to access this class of compounds has appeared in the literature. This review shows the different approaches for the enantioselective synthesis of azaflavanones based on asymmetric catalysis.

Cite this article as:

Pinheiro Sergio, Muri M.F. Estela *, Oliveira P. R. F. de Rafael, Dias R.S. Luiza and Greco J. Sandro, Asymmetric Catalysis in the Synthesis of Azaflavanones, Mini-Reviews in Organic Chemistry 2017; 14(5) . https://dx.doi.org/10.2174/1570193X14666170518120501