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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

Asymmetric Catalysis in the Synthesis of Azaflavanones

Author(s): Sergio Pinheiro, Estela M.F. Muri*, Rafael P. R. F. de Oliveira, Luiza R.S. Dias and Sandro J. Greco

Volume 14, Issue 5, 2017

Page: [400 - 406] Pages: 7

DOI: 10.2174/1570193X14666170518120501

Price: $65


Azaflavanones are synthetic aza-analogues of flavanones possessing several biological interests, especially as anticancer. Since individual enantiomers of azaflavanones showed different anticancer activities, the development of asymmetric routes to access this class of compounds has appeared in the literature. This review shows the different approaches for the enantioselective synthesis of azaflavanones based on asymmetric catalysis.

Keywords: Azaflavanones, Michael, aza-Michael, one-pot reactions, kinetic resolution, enantioselective epoxidation.

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