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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

Author(s): Juan M. Salas , Ana B. Caballero *, Ginés M. Esteban-Parra and José M. Méndez-Arriaga

Volume 24 , Issue 25 , 2017

Page: [2796 - 2806] Pages: 11

DOI: 10.2174/0929867324666170516122024

Price: $65


Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5- a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.

Keywords: Triazolopyrimidine, metal complexes, Leishmania, Trypanosoma cruzi, leishmaniasis, Chagas disease, neglected tropical diseases.

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