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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

A Therapeutic Potential of Animal β-hairpin Antimicrobial Peptides

Author(s): Pavel V. Panteleev, Sergey V. Balandin, Vadim T. Ivanov and Tatiana V. Ovchinnikova*

Volume 24, Issue 17, 2017

Page: [1724 - 1746] Pages: 23

DOI: 10.2174/0929867324666170424124416

Price: $65

Abstract

Endogenous antimicrobial peptides (AMPs) are evolutionary ancient molecular factors of innate immunity that play the key role in host defense. Because of the low resistance rate, AMPs have caught extensive attention as possible alternatives to conventional antibiotics. Over the last years, it has become evident that biological functions of AMPs are beyond direct killing of microbial cells. This review focuses on a relatively small family of animal host defense peptides with the β-hairpin structure stabilized by disulfide bridges. Their small size, rigid structure, stability to proteases, and plethora of biological functions, including antibacterial, antifungal, antiviral, anticancer, endotoxin-binding, metabolism- and immune- modulating activities, make natural β-hairpin AMPs an attractive molecular basis for drug design.

Keywords: Antimicrobial peptides, host defense, innate immunity, peptide therapeutics, β-hairpin structure, disulfide bridge.


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