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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

FledFold: A Novel Software for RNA Secondary Structure Prediction

Author(s): Qi Zhao, Yuanning Liu, Yunna Duan, Tao Dai, Rui Xu, Hao Guo, Daiming Fan, Yongzhan Nie and Hao Zhang*

Volume 14, Issue 9, 2017

Page: [714 - 716] Pages: 3

DOI: 10.2174/1570178614666170419122621

open access plus


Background: RNA secondary structure is essential to understand the mechanism of RNAs.

Method: In this paper, fledFold, a novel software for RNA secondary structure prediction, is introduced. It combines both thermodynamic and kinetic factors of RNA secondary structures and can predict RNA secondary structures from their primary sequences with local personal computers.

Results: FledFold is implemented in C++ under Windows 7 and could run on windows 7 or later version with at least 2 GB of RAM. Fledfold is user friendly and could output results with multiple formats.

Conslusion: FledFold will be a valuable tool for RNA researches and it could be downloaded freely from

Keywords: Bioinformatics tools, computer, molecule structure, RNA secondary structure prediction, software, primary sequences.

Graphical Abstract

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