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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Myocardial Infarction. Pathological Relevance and Relationship with Coronary Risk Factors

Author(s): Aurelio Leone*

Volume 23, Issue 22, 2017

Page: [3205 - 3216] Pages: 12

DOI: 10.2174/1381612823666170317123426

Price: $65


Background: Three types of necrosis characterize MI: coagulation necrosis, typically due to a coronarogenic mechanism, coagulative myocytolysis with formation of contract bands as an effect of sympathetic nervous system and adrenergic stimulation, and colliquative myocytolysis, characterized by myocardial fiber lysis, which is a close result of hydrolytic enzyme activity deriving from the material reaching the infarct area.

Methods: Although a multifactorial etiology may be identified, nevertheless coronary alterations, which are a consequence of atherosclerotic plaque formation and complications with a reduced blood flow supply to the myocardium, are the benchmark of MI.

Results: Evidence indicates a close relationship between the MI and some coronary risk factors, associated with this pathologic pattern with a different, but high rate.

Conclusion: Precipitating events to cause acute myocardial pathology need, however, to develop an acute myocardial infarction.

Keywords: Myocardial infarction, coronary pathology, sympathetic nervous system, catecholamine release, myocardial necrosis, coronary risk factor(s).

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