Abstract
Background: Dendrimers are hyperbranched polymeric nanomaterials increasingly used in research, industrial and biomedical applications. Establishing safety profile of these particles includes an understanding of their interactions with blood components and the immune system.
Method: Herein I review the literature demonstrating how tuning dendrimer physicochemical properties influences their interaction with erythrocytes, platelets, plasma proteins, complement and coagulation systems. Dendrimer immunogenicity, adjuvanticity, allergenicity, anti-inflammatory, immunosuppressive and antibacterial properties are also discussed. Conclusion: Dendrimers hemato- and immune- compatibility are determined by particle size, architecture, type and density of surface functional groups. Case studies from the literature are discussed to support this conclusion. The review also highlights questions which require more thorough investigation to fill the gaps in our understanding of immunological properties of dendrimers.Keywords: Dendrimers, nanoparticles, vaccines, adjuvant, antigen, antibody.
Current Pharmaceutical Design
Title:Dendrimers Effects on the Immune System: Insights into Toxicity and Therapeutic Utility
Volume: 23 Issue: 21
Author(s): Marina A. Dobrovolskaia*
Affiliation:
- Leidos Biomedical Research Inc P.O. Box B, 1050 Boyles Street Frederick, MD 21702 – 1201,United States
Keywords: Dendrimers, nanoparticles, vaccines, adjuvant, antigen, antibody.
Abstract: Background: Dendrimers are hyperbranched polymeric nanomaterials increasingly used in research, industrial and biomedical applications. Establishing safety profile of these particles includes an understanding of their interactions with blood components and the immune system.
Method: Herein I review the literature demonstrating how tuning dendrimer physicochemical properties influences their interaction with erythrocytes, platelets, plasma proteins, complement and coagulation systems. Dendrimer immunogenicity, adjuvanticity, allergenicity, anti-inflammatory, immunosuppressive and antibacterial properties are also discussed. Conclusion: Dendrimers hemato- and immune- compatibility are determined by particle size, architecture, type and density of surface functional groups. Case studies from the literature are discussed to support this conclusion. The review also highlights questions which require more thorough investigation to fill the gaps in our understanding of immunological properties of dendrimers.Export Options
About this article
Cite this article as:
Dobrovolskaia A. Marina*, Dendrimers Effects on the Immune System: Insights into Toxicity and Therapeutic Utility, Current Pharmaceutical Design 2017; 23 (21) . https://dx.doi.org/10.2174/1381612823666170309151958
DOI https://dx.doi.org/10.2174/1381612823666170309151958 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anionic Antimicrobial Peptides from Eukaryotic Organisms
Current Protein & Peptide Science Liposomal Formulation of Monovalent Cholesteryl Cytofectins with Acyclic Head Groups and Gene Delivery: A Systematic Review
Current Pharmaceutical Biotechnology Characterization and Pharmacokinetic Evaluation of Gamma Sterilized Ketorolac Tromethamine Loaded Albumin Microspheres for Intramuscular Administration
Current Drug Delivery Developments of Combretastatin A-4 Derivatives as Anticancer Agents
Current Medicinal Chemistry Effect of Environmental Contaminants on Mammalian Testis
Current Molecular Pharmacology CRISPR/Cas9 Genome Editing Tool: A Promising Tool for Therapeutic Applications on Respiratory Diseases
Current Gene Therapy Arsenic trioxide Alters the MicroRNA Expression Profile of U87 glioblastoma
Anti-Cancer Agents in Medicinal Chemistry Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review
Recent Patents on Anti-Cancer Drug Discovery Cigarette Smoke Decreases Salivary 18 kDa Translocator Protein Binding Affinity – in Association with Oxidative Stress
Current Medicinal Chemistry New Trends in Fiber-Optic Chemical and Biological Sensors
Current Analytical Chemistry Involvement of Orbital Structures in Rheumatic Disease
Current Rheumatology Reviews Resveratrol and Lifespan in Model Organisms
Current Medicinal Chemistry Advances Towards The Discovery of GPR55 Ligands
Current Medicinal Chemistry Identification of HDACs Inhibitor E14 Metabolites Appeared in Rat Plasma, Feces and Urine by UPLC-QTOF-MS/MS
Current Pharmaceutical Analysis Anti-Cancer, Pharmacokinetic and Biodistribution Studies of Cremophor EL Free Alternative Paclitaxel Formulation
Current Drug Safety Castration Resistant Prostate Cancer: From Emerging Molecular Pathways to Targeted Therapeutic Approaches
Clinical Cancer Drugs FOXM1-Dependent Transcriptional Regulation of EZH2 Induces Proliferation and Progression in Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry Targeting ADAM17 Sheddase Activity in Cancer
Current Drug Targets Prediction by Pharmacogenetics of Safety and Efficacy of Non-Steroidal Anti- Inflammatory Drugs: A Review
Current Drug Metabolism Genetically Redirected T Lymphocytes for Adoptive Immunotherapy of Solid Tumors
Current Gene Therapy