Generic placeholder image

Current Drug Therapy

Editor-in-Chief

ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Review Article

Prodrugs to Codrugs

Author(s): Deepali Gangrade* and Ravindra Karande

Volume 12, Issue 1, 2017

Page: [29 - 36] Pages: 8

DOI: 10.2174/1573413713666170210095211

Price: $65

Abstract

Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other.

Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa.

Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically.

Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades.

Keywords: Prodrugs, codrugs, carrier linked prodrugs, spacer, benorylate.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy