摘要
背景:载脂蛋白E 4等位基因的存在是否与调节异常衰老的海马连接网络相关尚未完全阐明。 目的:研究在4型等位基因的阿尔茨海默病型、携带者和非携带者的神经退行性病变患者中,这种功能连接的等位基因依赖性差异。 方法:采用基于种子的连通性方法。两组在人口统计学、脑结构容积测量和认知轮廓上相似。 结果:ε4-carriers增加了连接的种子区之间的左侧海马和1)左岛叶、外侧前额叶区和2)侧右顶叶。此外,4型携带者的海马-顶叶连接与记忆成绩呈正相关,表明组间差异反映了代偿过程。功能连通性的回顾性分析基于患者从ADNI计划证实了这种模式 结论:我们认为,增加连接区域的默认模式网络(DMN)反映外部补偿补充区,病理缠绕之间的DMN和凸显网络作为一个全球性的ε4源环路中断部分。这些差异表明,ε4等位基因是即使在神经退行性疾病的前驱期与DMN网络故障更深刻的程度有关。
关键词: 功能连接,抑制假说,后扣带回、海马;阿尔茨海默病,网络中断。
Current Alzheimer Research
Title:ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer’s Disease Support Memory Performance
Volume: 14 Issue: 7
关键词: 功能连接,抑制假说,后扣带回、海马;阿尔茨海默病,网络中断。
摘要: Background: Whether the presence of the Apolipoprotein E ε4 allele modulates hippocampal connectivity networks in abnormal ageing has yet to be fully clarified.
Objective: Allele-dependent differences in this pattern of functional connectivity were investigated in patients with very mild neurodegeneration of the Alzheimer’s type, carriers and non-carriers of the ε4 allele. Method: A seed-based connectivity approach was used. The two groups were similar in demographics, volumetric measures of brain structure, and cognitive profiles. Results: ε4-carriers had increased connectivity between the seed area in the left hippocampus and 1) a left insular/lateral prefrontal region and 2) the contralateral right parietal cortex. Moreover, hippocampus- to-parietal connectivity in the group of ε4 carriers was positively associated with memory performance, indicating that the between-group difference reflects compensatory processes. Retrospective analyses of functional connectivity based on patients from the ADNI initiative confirmed this pattern. Conclusion: We suggest that increased connectivity with areas external to the Default Mode Network (DMN) reflects both compensatory recruitment of additional areas, and pathological interwining between the DMN and the salience network as part of a global ε4-dependent circuital disruption. These differences indicate that the ε4 allele is associated with a more profound degree of DMN network breakdown even in the prodromal stage of neurodegeneration.Export Options
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Cite this article as:
ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer’s Disease Support Memory Performance, Current Alzheimer Research 2017; 14 (7) . https://dx.doi.org/10.2174/1567205014666170206113528
DOI https://dx.doi.org/10.2174/1567205014666170206113528 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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