摘要
在过去,血脑屏障(BBB)主要表现为形成血管/毛细血管壁的内皮细胞层。最近,血脑屏障是一个高度动态和交互系统,其中一部分被称为神经血管单元(Nvu),包括血管内皮细胞、神经胶质细胞和神经元。 涉及BBB功能障碍的中枢神经系统疾病的数据正在迅速增长。血脑屏障的开放和随后血清成分向大脑的渗透会导致许多进程,例如导致渐进性突触和神经元功能障碍和丢失。这样的过程有牵连的不同的疾病,包括血管性痴呆、中风、阿尔茨海默病(AD),´帕金森´病、多发性硬化症、肌萎缩性侧索硬化症、缺氧、缺血、糖尿病。 tau蛋白的一组异质性的神经退行性疾病的特点是在20个不同的微管相关蛋白tau蛋白异常沉积在神经系统的细胞。 微血管通透性增加是淀粉样血管沉积相关的更一般β(一β),但相比之下很少是关于血脑屏障功能损伤和错误折叠的tau蛋白之间的连接称。在这里,我们回顾什么是已知的关于tau蛋白,血脑屏障,与改善。
关键词: tau蛋白病、阿尔茨海默病、神经血管单元,血脑屏障,tau蛋白。
Current Alzheimer Research
Title:Tauopathies – Focus on Changes at the Neurovascular Unit
Volume: 14 Issue: 7
关键词: tau蛋白病、阿尔茨海默病、神经血管单元,血脑屏障,tau蛋白。
摘要: In the past, the blood-brain barrier (BBB) has been characterized mainly as a layer of endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is considered to be a part of a highly dynamic and interactive system called the neurovascular unit (NVU), consisting of vascular cells, glial cells, and neurons.
The list of central nervous system (CNS) pathologies involving BBB dysfunction is rapidly growing. The opening of the BBB and subsequent infiltration of serum components to the brain can lead to a host of processes resulting in progressive synaptic and neuronal dysfunction and loss. Such processes have been implicated in different diseases, including vascular dementias, stroke, Alzheimer´s disease (AD), Parkinson´s disease, multiple sclerosis, amyotrophic lateral sclerosis, hypoxia, ischemia, and diabetes mellitus. Tauopathies represent a heterogeneous group of around 20 different neurodegenerative diseases characterized by abnormal deposition of microtubule-associated protein tau in cells of the nervous system. Increased microvascular permeability has been more typically related to cerebrovascular deposition of amyloid-β (Aβ), but in contrast very little is known about the connection between functional impairment of the BBB and the misfolded tau proteins. Here, we review what is known about tauopathies, the BBB, and the NVU.Export Options
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Cite this article as:
Tauopathies – Focus on Changes at the Neurovascular Unit, Current Alzheimer Research 2017; 14 (7) . https://dx.doi.org/10.2174/1567205014666170203143336
DOI https://dx.doi.org/10.2174/1567205014666170203143336 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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