Background: We created highly effective ointment on the basis of nanoparticles of silver and zinc. The ointment contains active nanoingredients that optimize the healing process. The ointment creates an optimal microenvironment reparative and has antiinflammatory properties. The drug has a high adsorption capacity; it does not have a local anti-irritant and allergic effects.Methods: Silver nanoparticles were prepared by reduction of silver nitrate (AgNO3) with sodium borohydride (NaBH4) in an aqueous medium in the presence of quaternary ammonium compounds (QAC). In our research, a nanoparticle ZnO was synthesized by the sol-gel method. The experiment on the study of the effect of the developed pharmaceutical hydrophilic ointment compositions on burn healing process behaviour was conducted on Wistar rats aged 6 months, weighing up to 250 grams in accordance with international requirements Guide for the Care And Use of Laboratory Animals and the Russian legislation. Results: As a result of the research, we obtained new pharmaceutical hydrophilic ointment compositions with different contents of active components, including nanoscale elements of silver and zinc oxide, which led to a complete recovery of animals in 16-18 days, 6-day faster than conventional treatments of thermal damage to the skin. Conclusion: The studies showed that the ointment composition has good regenerating, antioxidant and wound healing properties due to active proliferation of epithelial tissue in the wound defect area and complete integumentary structures regeneration. Such effect is ensured by the additional components of the ointment, such as glycerin and methyl cellulose, promoting the penetration of active components into the deep panniculus, ensuring the optimal therapeutic effect.