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Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Review Article

Overview of the Structure and Function of Protein Kinases

Author(s): Sugunadevi Sakkiah, Guang Ping Cao, Staya P. Gupta and Keun Woo Lee*

Volume 13, Issue 2, 2017

Page: [81 - 88] Pages: 8

DOI: 10.2174/1573408013666161226155608

Price: $65

Abstract

After G protein-coupled (GPC) receptors, protein kinases are considered as most important drug targets. Kinase family consists of multigene, which is particularly relevant to various diseases. Protein phosphorylation by kinases plays a crucial activity in many cellular processes like apoptosis, cell division, survival, metabolism, etc. The emergence of various protein kinases crystal structures from many research groups gives a deep insight to understand the catalysis and regulation of different protein kinases. This review will mainly focus on the active site structures and functions of few kinases related to different families such as Protein A, G, and C kinase family (AGC), Ca2+/Calmodulin-dependent kinase family (CaMK), Cyclin-dependent kinase family (CMGC), Receptor guanylatecyclase family (RGC), Tyrosine kinase family (TK), Tyrosine kinase-like family (TKL), Sterile 20 Serine/threonine kinase family (STE), and Casein kinase 1 family (CK1).

Keywords: AGC, CaMK, CMGC, protein kinases, tyrosine kinase.

Graphical Abstract

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