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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Cationic Transfection Lipids

Author(s): Dexi Liu, Tan Ren and Xiang Gao

Volume 10 , Issue 14 , 2003

Page: [1307 - 1315] Pages: 9

DOI: 10.2174/0929867033457386

Price: $65


This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.

Keywords: cationic lipids, gene delivery, liposomes, nonviral vectors, transfection

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