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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Cationic Liposomes as In Vivo Delivery Vehicles

Author(s): Nancy Smyth Templeton

Volume 10 , Issue 14 , 2003

Page: [1279 - 1287] Pages: 9

DOI: 10.2174/0929867033457421

Price: $65

Abstract

Optimization of cationic liposomal complexes for in vivo applications is complex involving many diverse components. These components include nucleic acid purification, plasmid design, formulation of the delivery vehicle, administration route and schedule, dosing, detection of gene expression, and others. This review will primarily focus on optimization of the delivery vehicle formulation. These formulation issues include morphology of the complexes, lipids used, flexibility versus rigidity, colloidal suspension, overall charge, serum stability, half-life in circulation, biodistribution, delivery to and dissemination throughout target tissues. Optimizing all components of the delivery system will allow broad use of liposomal complexes to treat or cure human diseases or disorders.

Keywords: liposomes, non-viral delivery, gene therapy, systemic delivery, formulation optimization, lamellar structures, colloidal suspensions, serum stability


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