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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Cationic Lipid Vectors for Plasmid DNA Delivery

Author(s): Aaron Hirko, Fuxing Tang and Jeffrey A. Hughes

Volume 10 , Issue 14 , 2003

Page: [1185 - 1193] Pages: 9

DOI: 10.2174/0929867033457412

Price: $65

Abstract

Successful gene therapy depends on efficient gene transfer vectors. Viral vectors and non-viral vectors have been investigated extensively. Cationic lipids are non-viral vectors, which resemble traditional pharmaceuticals, display little immunogenicity, and have no potential for viral infection. However, toxicity and low transfection efficiency are two barriers limiting the clinical applications of cationic lipids. Over the last decade, hundreds of cationic lipids have been synthesized to address these problems. In this brief review, we summarized recent research results concerning the structures of DNA / liposomes complexes, some important strategies used to design different classes of cationic lipids, and use of disulfide cationic lipids in plasmid DNA delivery.

Keywords: disulfide, cationic lipid, plasmid dna, delivery, liposome


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