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Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Review Article

Pathophysiology of Myocardial Infarction and Acute Management Strategies

Author(s): Miha Tibaut, Dusan Mekis and Daniel Petrovic

Volume 14 , Issue 3 , 2016

Page: [150 - 159] Pages: 10

DOI: 10.2174/1871525714666161216100553

Price: $65

Abstract

On an annual basis, 13.2% of all deaths are attributable to coronary artery disease (CAD), which makes CAD - with 7.4 million deaths – the leading cause of death in the world. In this review, we discuss current knowledge in the pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation – myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, the ischemia-reperfusion injury, leftventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, a decision on the reperfusion strategy, timing and cardiac protection by ischemic preconditioning, post-conditioning and remote ischemic conditioning.

Keywords: Atherosclerosis, coronary artery disease, management, medical therapy, myocardial conditioning, myocardial infarction, pathophysiology.

Graphical Abstract

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