摘要
背景:感染人乳头状瘤病毒(HPV)引起多种恶性肿瘤,约占人类癌症的10-20%。最近开发的两种预防病毒感染的疫苗具有很强的免疫原性,可以提供长期保护。这些疫苗的使用大大降低了全世界妇女第二常见的癌症宫颈的发病率。然而,治疗疫苗可以消除已经存在的人乳头状瘤病毒感染和治疗现有的人乳头状瘤病毒引起的癌症,但是这些疫苗尚未开发。 方法:在这个简单的综述中,我们讨论了人乳头状瘤病毒相关癌症的免疫疗法和对人乳头状瘤病毒感染的免疫病理学的认识的进展。 结果:最近的研究进展表明,人乳头状瘤病毒感染引起的癌症以分子生物学方法靶向免疫治疗对于免疫治疗疫苗的开发有很大的潜力和前景。到目前为止,所测试的免疫疫苗绝大多数是针对人乳头状瘤病毒病毒的基因及其蛋白,尤其是E6和E7癌基因。 结论:发展的免疫疫苗的目的是提高细胞免疫功能,增强的细胞免疫就增强了机体抵御疾病和机体的自然防御能力,从而治疗现有的癌症。
关键词: 免疫治疗,人乳头状瘤病毒,免疫病理机制,癌症,病毒感染,免疫原性,免疫治疗。
Current Cancer Drug Targets
Title:Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers
Volume: 17 Issue: 6
关键词: 免疫治疗,人乳头状瘤病毒,免疫病理机制,癌症,病毒感染,免疫原性,免疫治疗。
摘要: Background: Infection with human papillomavirus (HPVs) causes many cancers, which account for about 10-20% of total human cancers. Two recently developed prophylactic vaccines against virus infection confer strong immunogenicity to provide long-term protection. The use of these vaccines has contributed to a substantial decrease in the rates of cervical cancer the second most common cancer of women worldwide. However, therapeutic vaccines that can eliminate preexisting HPV infections and treat an existing HPV-caused cancer have not been developed.
Method: In this short review, we discuss development of immunotherapy for HPV-associated cancers and recent progresses in our understanding of the immunopathology of HPV infection. Results: Recent research advances have shown that molecular approaches target to immunotherapy for HPV infection-induced cancers to have the great potential and promise for developing immunotherapeutic vaccines. So far, the vast majority of the immunotherapeutic vaccines that are being tested are designed to target HPV viral genes and their proteins especially two E6 and E7 oncogenes. Conclusion: The developing immunotherapeutic vaccines aim to boost cell-mediated immunity. The boosted cell-mediated immunity strengthens the body’s natural defenses to fight active infection and disease, thus to treat the existing cancers.Export Options
About this article
Cite this article as:
Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers, Current Cancer Drug Targets 2017; 17 (6) . https://dx.doi.org/10.2174/1568009616666161216094701
DOI https://dx.doi.org/10.2174/1568009616666161216094701 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacological Modulation of p53 Function in Cancer Therapy
Current Signal Transduction Therapy Relevance of Multidrug Resistance Proteins on the Clinical Efficacy of Cancer Therapy
Current Drug Delivery Seeds of Mung Bean (<i>Vigna radiata</i> (L.) R.Wilczek): Taxonomy, Phytochemistry, Medicinal Uses and Pharmacology
Current Bioactive Compounds Tumor Immune Escape Mechanisms that Operate During Metastasis
Current Pharmaceutical Biotechnology Translational Molecular Imaging in Drug Development: Current Status and Challenges
Current Medical Imaging Targeted Inhibition of Angiogenic Factors in AIDS-related Disorders
Current Drug Targets - Infectious Disorders Performance of PET/CT for Detecting the Primary Tumors of Cervical Metastases from Unknown Primary Carcinoma: A Systematic Review and Meta-Analysis
Current Medical Imaging A Review on Recent Technologies and Patents on Silica Nanoparticles for Cancer Treatment and Diagnosis
Recent Patents on Drug Delivery & Formulation New Potential Pharmaceutical Applications of Hypericum Species
Mini-Reviews in Medicinal Chemistry Using Cytokines to Treat Cervical Intraepithelial and Invasive Neoplasia
Recent Patents on Anti-Cancer Drug Discovery Predictive Efficacy Biomarkers of Programmed Cell Death 1/Programmed Cell Death 1 Ligand Blockade Therapy
Recent Patents on Anti-Cancer Drug Discovery Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets.
Mini-Reviews in Medicinal Chemistry Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility
Anti-Cancer Agents in Medicinal Chemistry On Molecular Graph Comparison
Current Computer-Aided Drug Design Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv
Anti-Cancer Agents in Medicinal Chemistry Combined Anticancer Therapies: An Overview of the Latest Applications
Anti-Cancer Agents in Medicinal Chemistry Template Dependent Human DNA Polymerases
Current Topics in Medicinal Chemistry PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress
Current Medicinal Chemistry Tirapazamine: From Bench to Clinical Trials
Current Clinical Pharmacology Radioimmunotherapy of Solid Tumors: Searching for the Right Target
Current Drug Delivery