Five Pediatric Cancers – Update on Genetic Implications

Title:Five Pediatric Cancers – Update on Genetic Implications

Volume: 13 Issue: 1

Author(s): Stacy Cooper, Jeffrey Rubens and Joann Bodurtha*

Affiliation:

• McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, 600 N. Wolfe St., Blalock 1008, Baltimore MD 21287,United States

Keywords: Brain tumors, cancer, genetics, leukemia, lymphoma, pediatrics, retinoblastoma, wilms tumor.

Abstract: Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric cancers continues to be improved.

Cite this article as:

Cooper Stacy, Rubens Jeffrey and Bodurtha Joann*, Five Pediatric Cancers – Update on Genetic Implications, Current Pediatric Reviews 2017; 13(1) . https://dx.doi.org/10.2174/1573396312666161213114223