摘要
背景:磷脂和他们的代谢机制与二型糖尿病致病原因和患者认知功能障碍紧密相关。这篇文章的目的是识别二型糖尿病人血浆中的磷脂水平和二型糖尿病人轻度认知功能障碍(MCI),同时鉴定轻度认知功能障碍的二型糖尿病人蛋白生物标志物。 方法:在这个横向研究中,共计374名二型糖尿病人前瞻性加入,其中103名病人患有MCI,271名没有患MCI。血浆溶血磷脂酸(LPA)水平和可溶性磷脂与试验中LPA(PSS-LPA)类似。 结果:血浆(LPA)和PSS-LPA水平在患有MCI的病人中显著高于没有患MCI的病人(P = 0.007, P < 0.001)。逻辑回归分析显示血浆PSSLPA评估与在二型糖尿病人中增加的MCI发病几率有关,在额外调节高脂血症,高血压,超敏C反应蛋白,糖化血红蛋白,内膜中层厚度,踝肱指数,肱踝脉搏波传导速度后OR为1.87 (1.04- 3.47)。在有着MCI的二型糖尿病人中,在血浆LPA,PSS-LPA和MoCA数中有负相关关系(r =﹣0.322, P < 0.01; r =﹣0.349, P < 0.001)。进一步说,血浆PSS-LPA展示出合理的MCI诊断价值,从面积在曲线0.86以下看出。 结论:血浆PSS-LPA水平对患有MCI的二型糖尿病人来说可能是重要的生物标记物。
关键词: 磷脂,二型糖尿病,轻度认知障碍,风险因素,血浆,生物标志物。
Current Alzheimer Research
Title:Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients
Volume: 14 Issue: 6
关键词: 磷脂,二型糖尿病,轻度认知障碍,风险因素,血浆,生物标志物。
摘要: Background: Phospholipids and their metabolisms are closely allied to nosogenesis and aggravation of Type 2 diabetes mellitus and cognitive impairment. The aim of this study is to characterize the plasma levels of phospholipids in type 2 diabetes patients and type 2 diabetes patients with mild cognitive impairment (MCI), and to identify potential biomarkers of type 2 diabetes patients with MCI.
Methods: In this cross-sectional study, a total of 374 type 2 diabetes patients were prospectively enrolled. There were 103 patients with MCI and 271 patients without MCI. Plasma levels of lysophosphatidic acid (LPA) and phospholipids with solubility similar to that of LPA (PSS-LPA) were assayed. Results: Plasma LPA and PSS-LPA levels were significantly higher in patients with MCI than those without MCI (P = 0.007, P < 0.001). A logistic regression analysis indicates that elevated plasma PSSLPA was associated with increased risk of MCI in type 2 diabetic patients, with an OR of 1.87 (1.04- 3.47) after additional adjustment for hyperlipidemia, hypertension, High-sensitivity C-reactive protein, hemoglobin A1c, Intima-media thickness, ankle brachial index, and brachial-ankle pulse wave velocity. In type 2 diabetic patients with MCI, there were negative correlations between plasma LPA, PSS-LPA and the MoCA scores (r =﹣0.322, P < 0.01; r =﹣0.349, P < 0.001). Furthermore, plasma PSS-LPA exhibited a fair diagnostic value for MCI, with an area under the curve of 0.86. Conclusion: The level of plasma PSS-LPA may be an important biomarker for diagnosis of MCI.Export Options
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Cite this article as:
Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients, Current Alzheimer Research 2017; 14 (6) . https://dx.doi.org/10.2174/1567205013666161201200722
DOI https://dx.doi.org/10.2174/1567205013666161201200722 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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