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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

Antioxidant Capacity of the Methanol Extract of Dysophylla auricularia

Author(s): Muhammad T. Islam*, Leonardo R. Sousa, Ana M.O.F. da Mata, Marcus V.O.B. de Alencar, Rosalia M.T. de Lima, Joao M.C. e Sousa and Ana A.C. Melo-Cavalcante

Volume 14 , Issue 1 , 2018

Page: [92 - 98] Pages: 7

DOI: 10.2174/1573407213666161128143915

Price: $65

Abstract

Brackground: In our previous study, we have shown that the ethanol, chloroform and nhexane extracts of Dysophylla auricularia revealed antimicrobial, anti-diarrheal, anti-inflammatory and membrane stabilization, alpha-glycosidase inhibitory and antipyretic activities. This study aims to evaluate the antioxidant capacity of methanol extract of D. auricularia (MDA) using some non-clinical test systems.

Materials and Methods: The methanol hot extract of the herb was undergone for six in vitro and one ex vivo and one in vivo antioxidant assays. An alpha-tocopherol analogue, trolox (6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid) was taken as a standard for in vitro and ex vivo tests, while hydrogen peroxide (H2O2) as a stressor for in vivo assay.

Results: The results suggest MDA within 12.5 to 500 µg/ml exhibited prominent radical scavenging, reduction potential, and inhibition of hemolysis capacities. Additionally, MDA dose-dependently exhibited an antioxidative defense against H2O2 induced damage in Saccharomyces cerevisiae (in vivo) test strains.

Conclusion: D. auricularia may be one of the potential sources of antioxidant compounds.

Keywords: Dysophylla auricularia, antioxidant, Rattus norvegicus, Saccharomyces cerevisiae, hemolysis.

Graphical Abstract

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