Abstract
Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.
Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively. Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.Keywords: Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.
Letters in Drug Design & Discovery
Title:Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure
Volume: 14 Issue: 6
Author(s): Ligia Souza da Silveira Pinto, Marcus V. N. de Souza*Carlos R. Kaiser
Affiliation:
- Instituto de Tecnologia em Fármacos-Far-Manguinhos, FioCruz-Fundação Oswaldo Cruz, P.O. Box: 21041- 250, Rio de Janeiro,Brazil
Keywords: Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.
Abstract: Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.
Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively. Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.Export Options
About this article
Cite this article as:
da Silveira Pinto Souza Ligia, de Souza V. N. Marcus*, Kaiser R. Carlos, Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure, Letters in Drug Design & Discovery 2017; 14 (6) . https://dx.doi.org/10.2174/1570180814666161121120414
DOI https://dx.doi.org/10.2174/1570180814666161121120414 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Tailored Multi-Target Agents. Applications and Design Considerations
Current Pharmaceutical Design Chemokines and Defensins as HIV Suppressive Factors: An Evolving Story
Current Pharmaceutical Design Antibacterial Activity and Structure-Activity Relationship Studies of 4- aryl/alkyl-1-(diphenylacetyl)thiosemicarbazides
Letters in Drug Design & Discovery Importance of a Potential Salt Bridge and Hydrophobic Core in the Function and Oligomerization of a Small Heat Shock Protein
Protein & Peptide Letters Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies
Current Organic Synthesis Interethnic and Intraethnic Variability of NAT2 Single Nucleotide Polymorphisms
Current Drug Metabolism Proteasome Structure, Function, and Lessons Learned from Beta-Lactone Inhibitors
Current Topics in Medicinal Chemistry QSAR as a Random Event: Selecting of the Molecular Structure for Potential Anti-tuberculosis Agents
Anti-Infective Agents Predicting Experimental Properties of Proteins from Sequence by Machine Learning Techniques
Current Protein & Peptide Science Design, Synthesis and In Vitro Biological Evaluation of Pyridine, Thiadazole, Benzimidazole and Acetyl Thiophene Analogues as Anti Tubercular Agents Targeting Enzyme Inh A
Current Computer-Aided Drug Design Stroke and COVID-19 Pandemic: The Dilemma
Coronaviruses Chlorella vulgaris Induces Apoptosis of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells
Medicinal Chemistry Vitamins B1, B2, B3 and B9 – Occurrence, Biosynthesis Pathways and Functions in Human Nutrition
Mini-Reviews in Medicinal Chemistry Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Effects of Edible Algae Polysaccharides on Allergic, Inflammatory, and Anti-Tumor Responses Through Toll-Like Receptor 4
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Adenovirus and Post-Infectious Bronchiolitis Obliterans in Children
Current Pediatric Reviews Virtual Screening of Drugs: Score Functions, Docking, and Drug Design
Current Computer-Aided Drug Design Advances in Lipid-Based Subunit Vaccine Formulations
Current Immunology Reviews (Discontinued) Antibacterial Activity of Cissus incisa Extracts against Multidrug- Resistant Bacteria
Current Topics in Medicinal Chemistry Vitamin, Mineral, and Drug Absorption Following Bariatric Surgery
Current Drug Metabolism