Caffeine; the Forgotten Potential for Parkinson's Disease

Title:Caffeine; the Forgotten Potential for Parkinson's Disease

Volume: 16 Issue: 6

Author(s): Ahmed Negida*, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Doaa Attia and Hussein Ahmed

Affiliation:

• Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Postal Code: 44519,Egypt

Keywords: Adenosine receptors, Caffeine, Dopamine, Lewy bodies, Parkinson's disease, tremors.

Abstract: Background: Parkinson’s disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies.

Method and Results: The literature suggests that caffeine plays multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation. On the level of mitochondrial stress, caffeine acts as an antioxidant that reduces oxidative stress in PD and therefore, slows the progression of the disease. On the level of dopamine release, the literature suggests that caffeine increases dopamine release and the number of dopamine receptors in the striatum via A2a receptor antagonism.

Conclusion: As an adjuvant treatment, caffeine interacts with antiparkinsonian medications and can alter levodopa pharmacokinetics, reduce dyskinesia, and improve gait in patients with freezing of gait. In this review, we discussed the potential of caffeine as a possible neuroprotective agent and as an addon therapy for PD.

Cite this article as:

Negida Ahmed*, Elfil Mohamed, Attia Attia, Farahat Eslam, Gabr Mohamed, Essam Ahmed, Attia Doaa and Ahmed Hussein, Caffeine; the Forgotten Potential for Parkinson's Disease, CNS & Neurological Disorders - Drug Targets 2017; 16(6) . https://dx.doi.org/10.2174/1871527315666161107091149

DOI https://dx.doi.org/10.2174/1871527315666161107091149	Print ISSN 1871-5273
Publisher Name Bentham Science Publisher	Online ISSN 1996-3181