Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities

Title:Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities

Volume: 17 Issue: 17

Author(s): Md Jawaid Akhtar, M. Shahar Yar*, Ahsan Ahmed Khan, Zulphikar Ali and Md Rafi Haider

Affiliation:

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi- 110062,India

Keywords: Antitumor, apoptosis, cell cycle analysis, cytotoxic, SARs, heterocyclic.

Abstract: Objective: The present review article presented a detailed account of the design strategies and the structure activity relationship of different derivatives apart from the nitrogen containing ring. These scaffolds play an important part in the drug discovery which showed anticancer activity against different human cancer cell lines through apoptosis, cell cycle arrest, inhibiting kinases, angiogenesis, disruption of cell migration, modulation of nuclear receptor responsiveness and others. Naphthalenes amides/amidines, furan, podophyllotoxin, platinum compounds, steroids, and urea, which forms the core part or along with other N-heterocyclic rings are enclosed. Some of these compounds e.g. podophyllotoxin and platinum based drugs displayed anticancer activity at nanomolar range. Various substitutions from the earlier and latest information are prerequisite in the drug synthesis process.

Conclusion: The review focused on the recent development of these derivatives, design and anticancer properties, thus providing with the most profound knowledge for the development of targeted based anticancer drugs.

Cite this article as:

Akhtar Jawaid Md, Yar Shahar M.*, Khan Ahmed Ahsan, Ali Zulphikar and Haider Rafi Md, Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities, Mini-Reviews in Medicinal Chemistry 2017; 17(17) . https://dx.doi.org/10.2174/1389557516666161031121639