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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Review Article

Gallium-68 in Medical Imaging

Author(s): Lucia Martiniova, Louis De Palatis, Elba Etchebehere and Gregory Ravizzini

Volume 9, Issue 3, 2016

Page: [187 - 207] Pages: 21

DOI: 10.2174/1874471009666161028150654

open access plus

Abstract

Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with 68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator. Because of the compact size and ease of use of the generator, 68Ga labeled compounds may be more cost-effective than PET radioisotopes that are cyclotron-produced. The convenient half-life of 68Ga (T1/2=68 min) provides sufficient radioactivity for various PET imaging applications, while delivering acceptable radiation doses to patients. This chapter summarizes the emerging clinical utilization of 68Ga-based radiotracers in medical imaging.

Keywords: 68Gallium, generator, neuroendocrine tumors, positron emission tomography, somatostatin receptor scintigraphy, PSMA.

Graphical Abstract

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