Review Article

microRNA Decay: Refining microRNA Regulatory Activity

Author(s): Genevieve Pepin and Michael P. Gantier*

Volume 5, Issue 3, 2016

Page: [167 - 174] Pages: 8

DOI: 10.2174/2211536605666161027165915

Abstract

MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.

Keywords: Cleavage, degradation, exosome, microRNA, RNase, target mRNA.

Graphical Abstract

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