Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety

Title:Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety

Volume: 14 Issue: 7

Author(s): Khaled R. A. Abdellatif*, Mohamed A. Abdelgawad, Heba A. H. Elshemy, Nesma M. Kahk and Dalia M. El Amir

Affiliation:

• Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni- Suef,Egypt

Keywords: Coumarin, pyrazole, isoxazole, thiazole, antioxidant, anticancer.

Abstract: Background: Three new series of coumarin derivatives 4a-e, 6a-d and 7a-d were synthesized and characterized by elemental analyses and spectral data including 2D NMR. All compounds 4a-e, 6a-d and 7a-d were evaluated for their in vitro antioxidant and anticancer activity against Hep-G2 hepatic cancer and MCF-7 breast cancer cell lines.

Cite this article as:

Abdellatif R. A. Khaled*, Abdelgawad A. Mohamed, Elshemy A. H. Heba, Kahk M. Nesma and El Amir M. Dalia, Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety, Letters in Drug Design & Discovery 2017; 14 (7) . https://dx.doi.org/10.2174/1570180813666161026153743