Abstract
Introduction: With the development of the direct acting antivirals aganist hepatitis C virus (HCV), the treatment of HCV has showed significiant progress. However, hepatitis B virus (HBV) therapy is still a topic of discussion.
Objectives: Because of that approved agents for HBV have some disadvantages including indefinite therapy, drug resistance, adverse effects and persistence of covalently closed circular deoxyribonucleic acid (cccDNA), there is a need for new treatment targets and approaches for HBV. And, there are several trials about this subject. New treatment targets for HBV consist revers transcription, immunoregulation, cccDNA formation and regulation, maturation and secretion of infectious virions and subviral particules, viral receptor, entry and cytosolic transport, nucleocapsid assembly. Therapeutic vaccination and traditional Chinese medicine are the other options for novel agents for HBV treatment. We summarised new treatment targets and approaches for HBV. Conclusion: It is a certain fact that large-scale studies about all these molecules and approaches are required, in order to highlight the efficiency, drug interaction, safety and appropriate dose.Keywords: Hepatitis B virus, treatment, nucleos(t)id analogues, cccDNA, immunoregulators, viral entry, traditional Chinese medicine.
Anti-Infective Agents
Title:New Treatment Targets and Approaches for Hepatitis B Virus
Volume: 15 Issue: 1
Author(s): Murat Afyon*Cumhur Artuk
Affiliation:
- GATA Haydarpasa Training Hospital, Primary Care and Examination, Family Health Center and the Naval Academy Clinic, Tuzla/Istanbul,Turkey
Keywords: Hepatitis B virus, treatment, nucleos(t)id analogues, cccDNA, immunoregulators, viral entry, traditional Chinese medicine.
Abstract: Introduction: With the development of the direct acting antivirals aganist hepatitis C virus (HCV), the treatment of HCV has showed significiant progress. However, hepatitis B virus (HBV) therapy is still a topic of discussion.
Objectives: Because of that approved agents for HBV have some disadvantages including indefinite therapy, drug resistance, adverse effects and persistence of covalently closed circular deoxyribonucleic acid (cccDNA), there is a need for new treatment targets and approaches for HBV. And, there are several trials about this subject. New treatment targets for HBV consist revers transcription, immunoregulation, cccDNA formation and regulation, maturation and secretion of infectious virions and subviral particules, viral receptor, entry and cytosolic transport, nucleocapsid assembly. Therapeutic vaccination and traditional Chinese medicine are the other options for novel agents for HBV treatment. We summarised new treatment targets and approaches for HBV. Conclusion: It is a certain fact that large-scale studies about all these molecules and approaches are required, in order to highlight the efficiency, drug interaction, safety and appropriate dose.Export Options
About this article
Cite this article as:
Afyon Murat*, Artuk Cumhur, New Treatment Targets and Approaches for Hepatitis B Virus, Anti-Infective Agents 2017; 15 (1) . https://dx.doi.org/10.2174/2211352514666161025113118
DOI https://dx.doi.org/10.2174/2211352514666161025113118 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Influence of Macrophages and the Tumor Microenvironment on Natural Killer Cells
Current Molecular Medicine Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?
Current Vascular Pharmacology Drug Eluting Stents and Beyond
Current Pharmaceutical Design Potential Protective Effects of Cannabidiol on Neuroanatomical Alterations in Cannabis Users and Psychosis: A Critical Review
Current Pharmaceutical Design Editorial [ Reducing Cardiovascular Risk: Is Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering Enough? ]
Current Vascular Pharmacology Estrogen Receptor Alpha: Impact of Ligands on Intracellular Shuttling and Turnover Rate in Breast Cancer Cells
Current Cancer Drug Targets Humoral and Cellular Immunity Against Cryptosporidium Infection
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Current and Future Challenges in Primary Sjogren’s Syndrome
Current Pharmaceutical Biotechnology HIV Vaccines in Infants and Children: Past Trials, Present Plans and Future Perspectives
Current Molecular Medicine Non-glycemic Adverse Effects of Insulin
Current Diabetes Reviews Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut
Current Protein & Peptide Science New Issues for Copper-64: from Precursor to Innovative Pet Tracers in Clinical Oncology
Current Radiopharmaceuticals Role of Stromal-Derived Factor-1 in Mesenchymal Stem Cell Paracrinemediated Tissue Repair
Current Stem Cell Research & Therapy The Critical Role of Toll-Like Receptor Signaling Pathways in the Induction and Progression of Autoimmune Diseases
Current Molecular Medicine Characteristics Other than the Diagnostic Criteria Associated with Metabolic Syndrome: An Overview
Current Vascular Pharmacology Therapies Targeting Innate Immunity for Fighting Inflammation in Atherosclerosis
Current Pharmaceutical Design The Relationship Between Social Support, Social Constraint, and Psychological Adjustment for Patients with Rare Autoimmune Disease
Current Rheumatology Reviews Review of Erectile Dysfunction in Diabetic Animal Models
Current Diabetes Reviews Are Antipsychotics Useful in the Treatment of Anorexia Nervosa? A Review of the Literature
Current Psychopharmacology Stem Cell Ageing and Apoptosis
Current Pharmaceutical Design