Enhancement of Dissolution Profile of Poorly Water Soluble Drugs by Using Techniques of Nanocrystallization

Title:Enhancement of Dissolution Profile of Poorly Water Soluble Drugs by Using Techniques of Nanocrystallization

Volume: 6 Issue: 3

Author(s): Anju Gauniya, Rupa Mazumder and Kamla Pathak

Affiliation:

Keywords: Nanocrystals, aceclofenac, solubility, particle size, drug, homogenization, amorphous.

Abstract: Background: The weak water solubility is the main problem to develop the highly potent pharmaceuticals. Nowadays to improve the solubility of various formulations containing nanocrystals, specific strategies are involved for their dissolution and bioavailability.

Objective: The objective of the present work was to improve the solubility of low watersoluble aceclofenac by preparing stable nanocrystals.

Methods: The methods for preparing the aceclofenac nanocrystals was carried out with the help of combination of precipitation process by using antisolvent and high pressure homogenization required for stability and converting them into fine and dry crystals by using spray-drying. The drug and its nanocrystals were characterized for SEM, FT- IR and XRD as well as measuring the particle size.

Results: The XRD results indicated that the antisolvent precipitation with high-pressure homogenization process led to the crystallization of aceclofenac. The nanocrystals thus produced lead to the stabilization of drugs by adsorption of the stabilizers onto the drug surface. Aceclofenac nanocrystals increased the solubility of drug by almost fourfold. The combination of two methods for forming nanocrystals leads to the formation of a stable formulation which showed increase in the solubility by increment in effective surface area and amorphous nature of drug.

Cite this article as:

Gauniya Anju, Mazumder Rupa and Pathak Kamla, Enhancement of Dissolution Profile of Poorly Water Soluble Drugs by Using Techniques of Nanocrystallization, Current Nanomedicine 2016; 6 (3) . https://dx.doi.org/10.2174/2468187306666161021103832

DOI https://dx.doi.org/10.2174/2468187306666161021103832	Print ISSN 2468-1873
Publisher Name Bentham Science Publisher	Online ISSN 2468-1881