Abstract
Background: The growing interest on the redox modulation in living systems broadly involved selenium derivatives that during the last twenty years were often claimed powerful antioxidants but that were also clearly correlated to several important biological effects sometimes, unfortunately, associated to a certain toxicity. Comparing the antioxidant activity of different organoselenium structures it can be observed that sometimes quite different reaction mechanisms are involved.
Method: We propose here a classification based on the nature of the selenenylated functional group. Beside the natural glutathione peroxidase-like activity, other biological interactions were proposed and we report now an overview of the state of art pointing the attention also to the testes used to evaluate and demonstrate the biological activity.
Conclusion: New prospective on the use of selenium and tellurium derivatives as Redox modulators, were discussed throughout a series of selected examples. The possibility to obtain from organoselenium derivatives molecules endowed with hormetic effect or able to act as selective inhibitor of specific enzyme will be discussed.
Keywords: Selenium, tellurium, redox, ROS, antioxidant, diselenide, selenide, ebselen.
Current Organic Chemistry
Title:New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds
Volume: 21 Issue: 20
Author(s): Angelita M. Barcellos, Laura Abenante, Maria Teresa Sarro, Iris Di Leo, Eder J. Lenardao, Gelson Perin*Claudio Santi*
Affiliation:
- LASOL - CCQFA - Universidade Federal de Pelotas - UFPel - P.O. Box 354 - 96010-900, Pelotas, RS,Brazil
- Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1- 06136 Perugia,Italy
Keywords: Selenium, tellurium, redox, ROS, antioxidant, diselenide, selenide, ebselen.
Abstract: Background: The growing interest on the redox modulation in living systems broadly involved selenium derivatives that during the last twenty years were often claimed powerful antioxidants but that were also clearly correlated to several important biological effects sometimes, unfortunately, associated to a certain toxicity. Comparing the antioxidant activity of different organoselenium structures it can be observed that sometimes quite different reaction mechanisms are involved.
Method: We propose here a classification based on the nature of the selenenylated functional group. Beside the natural glutathione peroxidase-like activity, other biological interactions were proposed and we report now an overview of the state of art pointing the attention also to the testes used to evaluate and demonstrate the biological activity.
Conclusion: New prospective on the use of selenium and tellurium derivatives as Redox modulators, were discussed throughout a series of selected examples. The possibility to obtain from organoselenium derivatives molecules endowed with hormetic effect or able to act as selective inhibitor of specific enzyme will be discussed.
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Cite this article as:
Barcellos M. Angelita, Abenante Laura, Sarro Teresa Maria, Leo Di Iris, Lenardao J. Eder, Perin Gelson*, Santi Claudio*, New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272820666161020162113
DOI https://dx.doi.org/10.2174/1385272820666161020162113 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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