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Current Microwave Chemistry


ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Research Article

Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling

Author(s): Aniket P. Sarkate*, Dattatraya N. Pansare, Kshipra S. Karnik, Ishwari A. Kale, Sushilkumar S. Bahekar and Devanand B. Shinde

Volume 4 , Issue 2 , 2017

Page: [163 - 167] Pages: 5

DOI: 10.2174/2213335603666161017120230

Price: $65


Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for substituted benzamides has been developed by using salts of carboxylic acids.

Methods: In the synthetic method, the targeted substituted benzamides were synthesized with the help of microwave by reacting salts of carboxylic acid and benzamides in the presence of copper and dimethyl formamide.

Results: All substituted benzamides were obtained in good yield (93-99%) with the help of a microwave technique (12-15 min) in the less time as compared to the conventional method.

Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of diverse range of substituted benzamides.

Keywords: Benzamides, copper, coupling, microwave, synthesis.

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