Abstract
NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the “gold standard” procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis. Nonetheless, given it is an invasive, painful and costly procedure, a great research efforts have been made in order to develop non-invasive methods for the assessment of NAFLD presence and/or severity by serum markers and imaging techniques. In this review we aimed to perform a comprehensive review of the literature about strengths and weaknesses of the main tools available for the non-invasive assessment of NAFLD patients.
Keywords: NAFLD, NASH, steatosis, non-invasive assessment, liver biopsy.
Current Molecular Medicine
Title:Non-Invasive Assessment of Liver Injury in Non-Alcoholic Fatty Liver Disease: A Review of Literature
Volume: 16 Issue: 8
Author(s): M. Maida, F. S. Macaluso, F. Salomone and S. Petta
Affiliation:
Keywords: NAFLD, NASH, steatosis, non-invasive assessment, liver biopsy.
Abstract: NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the “gold standard” procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis. Nonetheless, given it is an invasive, painful and costly procedure, a great research efforts have been made in order to develop non-invasive methods for the assessment of NAFLD presence and/or severity by serum markers and imaging techniques. In this review we aimed to perform a comprehensive review of the literature about strengths and weaknesses of the main tools available for the non-invasive assessment of NAFLD patients.
Export Options
About this article
Cite this article as:
Maida M., Macaluso S. F., Salomone F. and Petta S., Non-Invasive Assessment of Liver Injury in Non-Alcoholic Fatty Liver Disease: A Review of Literature, Current Molecular Medicine 2016; 16 (8) . https://dx.doi.org/10.2174/1566524016666161004143613
DOI https://dx.doi.org/10.2174/1566524016666161004143613 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Alginate Bead-Encapsulated PEDF Induces Ectopic Bone Formation In Vivo in the Absence of Co-Administered Mesenchymal Stem Cells
Current Drug Targets Editorial (Hot Topic: Targeted Therapies in the Treatment of Breast Cancer and Localized Sarcomas)
Current Medicinal Chemistry Inhibiting TLR9 Signaling Stimulates Apoptosis and Cell Cycle Arrest, and Alleviates Angiogenic Property in Human Cervical Cancer Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Metallocarboxypeptidases: Emerging Drug Targets in Biomedicine
Current Pharmaceutical Design Function and Malfunction of the Immune Cell-Adipocytes Axis and its Modulation by Natural Products and Probiotics
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) NMDA Receptors in Glial Cells: Pending Questions
Current Neuropharmacology Cerebral Hypoperfusion During Carotid Artery Stenosis can Lead to Cognitive Deficits that may be Independent of White Matter Lesion Load
Current Neurovascular Research A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications
Current Diabetes Reviews Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators
Letters in Drug Design & Discovery Interactions Between Probiotic Dairy Propionibacteria and the Intestinal Epithelium
Current Immunology Reviews (Discontinued) The PKB/AKT Pathway in Cancer
Current Pharmaceutical Design Renewable Energy via Photocatalysis
Current Organic Chemistry GSK-3 Inhibitors: Recent Developments and Therapeutic Potential
Current Signal Transduction Therapy Endothelial Progenitors in Vascular Repair and Angiogenesis: How Many are Needed and What to do?
Cardiovascular & Hematological Disorders-Drug Targets The Hypothalamus and Obesity
Current Drug Targets Receptor Tyrosine Kinases as Therapeutic Targets the Model of the MET Oncogene
Current Drug Targets Glycation of Human Serum Albumin in Diabetes: Impacts on the Structure and Function
Current Medicinal Chemistry Genes, Environment, and Interactions in Prevention of Type 2 Diabetes: A Focus on Physical Activity and Lifestyle Changes
Current Molecular Medicine Methadone and the Heart: What the Clinician Needs to Know
Current Drug Abuse Reviews Bacterial Infection Probes and Imaging Strategies in Clinical Nuclear Medicine and Preclinical Molecular Imaging
Current Topics in Medicinal Chemistry