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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Research Article

Anti-biofilm and Antibacterial Effects of Novel Metal-coordinated Sulfamethoxazole Against Escherichia coli

Author(s): Caren Rigon Mizdal, Sílvio Terra Stefanello, Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Vanessa da Costa Flores, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Lenice de Lourenco Marques and Marli Matiko Anraku de Campos

Volume 14 , Issue 3 , 2017

Page: [339 - 344] Pages: 6

DOI: 10.2174/1570180813666160930101653

Price: $65

Abstract

Background: Escherichia coli has an adaptive metabolism and many strains are resistant to classical antibacterial agents, and due to this resistance, it can cause severe clinical infections. In addition, few novel antibacterial agents have been developed in recent years, which corroborate with antimicrobial resistance. For this reason, innovative antimicrobials with novel targets and modes of action are needed.

Objective: The aim of this study was to determine the antibacterial and anti-biofilm activity of metals (mercury, copper, silver, and cadmium) coordinated with sulfamethoxazole (SMZ) against Escherichia coli (ATCC® 35218TM).

Methods: We used the minimum inhibitory concentration (MIC) technique to evaluate the compound antibacterial properties. Additionally, we verified metal-coordinated SMZ efficacy against bacterial motility, slime production and biofilm formation. We also quantified the bacterial respiratory activity in the presence of those compounds.

Results: We showed that metal-coordinated SMZ displayed E. coli antibacterial activities in concentrations are lower than the ones found to SMZ. Besides, metal-coordinated SMZ were able to inhibit biofilm formation and also decrease E. coli motility in lower concentrations than found in a classical antibiotic. All tested compounds stimulated the bacteria respiratory chain, which can be related to the mechanism of their antibacterial activity.

Conclusion: Our results suggest that metal-coordinated SMZ enhanced the antibacterial and anti-biofilm activity against E. coli when compared with SMZ free.

Keywords: Antibacterial properties, biofilm formation, metal-coordinated SMZ, respiratory activity, sulfamethoxazole.

Graphical Abstract

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