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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review

Author(s): Elena A. Chugunova and Alexander R. Burilov

Volume 17 , Issue 9 , 2017

Page: [986 - 1005] Pages: 20

DOI: 10.2174/1568026616666160927145822

Price: $65

Abstract

Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016).

Keywords: Furoxan, Benzofuroxan, NO-donor, Hybrid, Pharmacophore.


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