Abstract
Background: Antibody phage display is highly dependent on the availability of antibody libraries. There are several forms of libraries depending mainly on the origin of the source materials. There are three major classes of libraries, mainly the naïve, immune and synthetic libraries.
Methods: Immune antibody libraries are designed to isolate specific and high affinity antibodies against disease antigens. The pre-exposure of the host to an infection results in the production of a skewed population of antibodies against the particular infection.
Results: This characteristic takes advantage of the in vivo editing machinery to generate bias and specific immune repertoire. The skewed but diverse repertoire of immune libraries has been adapted successfully in the generation of antibodies against a wide range of diseases.
Conclusion: We envisage immune antibody libraries to play a greater role in the discovery of antibodies for diseases in the near future.
Keywords: Antibodies, antibody libraries, immune repertoire, phage display, therapeutic antibodies.
Current Pharmaceutical Design
Title:Immune Antibody Libraries: Manipulating The Diverse Immune Repertoire for Antibody Discovery
Volume: 22 Issue: 43
Author(s): Theam Soon Lim and Soo Khim Chan
Affiliation:
Keywords: Antibodies, antibody libraries, immune repertoire, phage display, therapeutic antibodies.
Abstract: Background: Antibody phage display is highly dependent on the availability of antibody libraries. There are several forms of libraries depending mainly on the origin of the source materials. There are three major classes of libraries, mainly the naïve, immune and synthetic libraries.
Methods: Immune antibody libraries are designed to isolate specific and high affinity antibodies against disease antigens. The pre-exposure of the host to an infection results in the production of a skewed population of antibodies against the particular infection.
Results: This characteristic takes advantage of the in vivo editing machinery to generate bias and specific immune repertoire. The skewed but diverse repertoire of immune libraries has been adapted successfully in the generation of antibodies against a wide range of diseases.
Conclusion: We envisage immune antibody libraries to play a greater role in the discovery of antibodies for diseases in the near future.
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About this article
Cite this article as:
Lim Soon Theam and Chan Khim Soo, Immune Antibody Libraries: Manipulating The Diverse Immune Repertoire for Antibody Discovery, Current Pharmaceutical Design 2016; 22 (43) . https://dx.doi.org/10.2174/1381612822666160923111924
DOI https://dx.doi.org/10.2174/1381612822666160923111924 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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