摘要
背景:男性生育控制需要精确的内分泌、旁分泌、自分泌通信以及下丘脑-垂体-性腺(HPG)轴。在这方面,upcoming/classical生殖功能调制器之间可能的相互作用值得关注,这可能是一个成功的工具,为未来的开发新的治疗生育障碍潜在的治疗方法的工具 方法:在本文中我们将讨论关于kisspeptins的数据以及它们在睾丸中可能的相互作用,kisspeptins是KISS1基因的产物并被认为是雌性激素。 结果:Kisspeptin,通过激活Kisspeptin受体GPR54从而释放促性腺激素激素(GnRH)和调节维持生殖功能。Kisspeptin信号损失导致人类和动物模型性腺机能减退。尽管在下丘脑水平中公认的作用,最近的数据表明kisspeptin直接产生,并能控制睾丸间质细胞,生殖细胞和精子的功能。同样,雌激素在睾丸中影响细胞增殖/凋亡、分化,从而为调节高质量的精子的产生,释放,运输和成熟。 结论:本文综述了关于kisspeptins和雌激素的睾丸活性保护男性生育力实验模型模型和人类模型的数据。并讨论了Kisspeptin和雌二醇信号对精子产生的影响。
关键词: Kiss1
Current Medicinal Chemistry
Title:Kisspeptins, Estrogens and Male Fertility
Volume: 23 Issue: 36
Author(s): Rosanna Chianese, Gilda Cobellis, Teresa Chioccarelli, Vincenza Ciaramella, Marina Migliaccio, Silvia Fasano and Riccardo Pierantoni, Rosaria Meccariello
Affiliation:
关键词: Kiss1
摘要: Background: The control of male fertility requires accurate endocrine, paracrine and autocrine communications along the hypothalamus-pituitary-gonad (HPG) axis. In this respect, the possible interplay between upcoming/classical modulators of reproductive functions deserves attention in that may be a successful tool for the future exploitation of new potential therapeutic targets in the treatment of fertility disorders.
Methods: In this review we will discuss upcoming data concerning the role of kisspeptins, the products of the Kiss1 gene, and estrogens - classically considered as female hormones - as well as their possible interplay in testis. Results: Kisspeptins, via the activation of kisspeptin receptor Gpr54 represent the main gatekeeper of the hypothalamic Gonadotropin Releasing Hormone (GnRH) centrally modulating the onset and maintaining reproductive functions. As a consequence, the loss of kisspeptin signalling causes hypogonadotrophic hypogonadism in humans and animal models. In spite of the well recognized functions at hypothalamic levels, recent data strongly support direct production and activity of kisspeptin in testis and its involvement in the control of Leydig cells, germ cells progression and sperm functions. Similarly, estrogens exhibit high impact on proliferative/apoptotic/differentiative events in testis, thus resulting as local key modulators for the production - but also for the release, transport and maturation - of high quality spermatozoa. Conclusion: This review summarizes the upcoming data from experimental models and humans concerning the testicular activity of kisspeptins and estrogens to preserve male fertility. Mutual enhancement of kisspeptin and estradiol signalling for the progression of spermatogenesis has also been discussed.Export Options
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Cite this article as:
Rosanna Chianese, Gilda Cobellis, Teresa Chioccarelli, Vincenza Ciaramella, Marina Migliaccio, Silvia Fasano and Riccardo Pierantoni, Rosaria Meccariello , Kisspeptins, Estrogens and Male Fertility, Current Medicinal Chemistry 2016; 23 (36) . https://dx.doi.org/10.2174/0929867323666160902155434
DOI https://dx.doi.org/10.2174/0929867323666160902155434 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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