Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

miRNAs in Melanoma: Tumor Suppressors and Oncogenes with Prognostic Potential

Author(s): Michal Wozniak, Aleksandra Mielczarek and Malgorzata Czyz

Volume 23, Issue 28, 2016

Page: [3136 - 3153] Pages: 18

DOI: 10.2174/1389557516666160831164544

Price: $65


MicroRNAs (miRNAs), which are small non-coding RNA molecules that post-transcriptionally regulate the expression of target genes, control the vast majority of cellular events, including proliferation, differentiation, survival, senescence, autophagy, metabolism and genome stability. Even slight alterations in miRNA expression levels may induce the development of pathological states, including cancer. Several studies have already demonstrated the importance of miRNAs in the regulation of melanocytes. Upregulation of oncogenic miRNAs (oncomiRs), mainly by amplification and translocation of miRNA genes, and downregulation of oncosuppressor miRNAs (anti-oncomiRs) by deletion and other mutations, promoter methylation and abnormal processing contributes to melanoma initiation and progression. At each phase of melanoma progression, tumor cells exhibit distinct profiles of miRNA expression, as compared with normal melanocytes. Moreover, as miRNAs are stable molecules that can be identified in bodily fluids, such as blood and saliva, they can serve as potent non-invasive prognostic markers of disease progression and response to therapy. This review summarizes recent findings regarding miRNA-mediated control of melanocytes and melanoma development, and presents miRNAs as prognostic markers for this disease.

Keywords: Melanocyte, melanogenesis, melanoma, oncomiR, anti-oncomiR, prognostic marker.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy