代谢物三甲胺-N-氧化物是人类健康的新兴生物标志物

Title:The Metabolite Trimethylamine-N-Oxide is an Emergent Biomarker of Human Health

Volume: 24 Issue: 36

关键词: 抗生素耐药，心脏代谢紊乱，饮食，草药，代谢产物，三甲胺-N-氧化物。

摘要: Trimethylamine-N-oxide (TMAO) is a low molecular weight metabolite whose production is dependent on metabolism of its precursors choline, carnitine, creatinine, betaine or lecithin by host gut microbes resulting in the synthesis of trimethylamine (TMA), which is subsequently oxidized to TMAO via hepatic flavin monooxygenase (FMO). TMAO is associated with microbial dysbiosis and is being studied for its linkage with cardiovascular disorders. In addition, dysregulated levels of TMAO have been linked with renal diseases, neurological disorders and cancer. Here we discuss the enzymatic and metabolic landscape that results in TMAO production, and in addition, collate data from numerous clinical studies that have assessed TMAO as a biomarker for various disease conditions. We also summarize the interaction of TMAO with modern and traditional drugs that together affect circulating TMAO levels in the human body.

Cite this article as:

The Metabolite Trimethylamine-N-Oxide is an Emergent Biomarker of Human Health, Current Medicinal Chemistry 2017; 24 (36) . https://dx.doi.org/10.2174/0929867323666160830104025