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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

Hydrogen Sulfide and Inflammatory Joint Diseases

Author(s): Elena F. Burguera*, Rosa Meijide-Failde and Francisco J. Blanco*

Volume 18 , Issue 14 , 2017

Page: [1641 - 1652] Pages: 12

DOI: 10.2174/1389450117666160829112824

Price: $65


Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in the brain, vasculature and other organs. Recent studies have found H2S to be a mediator in inflammatory joint diseases.

Objective: This review summarizes the recent literature in this area highlighting relevant developments.

Conclusions: Several authors have found that H2S exhibited anti-inflammatory, anti-catabolic and/or anti-oxidant effects in rodent models of acute arthritis and in in vitro models using human synoviocytes and articular chondrocytes from RA and OA tissues. The earliest studies used fast-dissolving salts, such as NaSH, but GYY4137, which produces H2S more physiologically, shortly appeared. More recently still, new H2S-forming compounds that target mitochondria have been synthesized. These compounds open exciting opportunities for investigating the role of H2S in cell bioenergetics, typically altered in arthritides. Positive results have also been obtained when H2S is administered as a sulphurous water bath, an option meriting further study. These findings suggest that exogenous supplementation of H2S may provide a viable therapeutic option for these diseases, particularly in OA.

Keywords: Inflammatory joint diseases, rheumatoid arthritis, osteoarthritis, hydrogen sulfide, mitochondria, sulphurous spring waters.

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